J.D. (Zach Braff), Turk (Donald Faison) and Elliot (Sarah Chalke) are two weeks into their hospital intern program and things are going well. The procedures are becoming easier and no one’s life has been endangered, yet. J.D. and Turk’s apartment has become a safe haven away from the stresses and challenges at the hospital. Elliot has started to become a frequent visitor at their apartment. Although he denies it, Turk thinks J.D. is interested in being more than just colleagues with Elliot. Meanwhile, Turk has his own eye on another member of the hospital staff, Carla (Judy Reyes), the nurse.

At the hospital, J.D., supervised by Dr. Cox (John C. McGinley) is assigned to Will Forte (John Ducey), a 31-year-old patient admitted with a serious case of pneumonia and possibly cancer. It turns out that the patient doesn’t have cancer, but J.D. tries to warn him about the possible effects of his 3-pack-a-day smoking habit might have in the future. The advice falls on deaf ears.

Elliot is having her own difficulties with Carla after Elliot told Dr. Kelso (Ken Jenkins) that Carla had neglected to run a test on a patient. The rest of the nurses side with Carla, until Elliot apologizes. But even the apology gets her into trouble again.

Turk’s numerous attempts to woo Carla fail, until she finally gives in and agrees to go on a date with him after he gives an impassioned speech.