The three interns are each assigned patients with various illnesses. Statistically speaking, one of the three will die. J.D.’s (Zach Braff) patient is 86-year-old Mrs. Tanner (Kathryn Joosten), who is in renal failure; Twenty-year-old David Morrison (Travis Webster) is Turk’s (Donald Faison) hernia patient and Elliot’s (Sarah Chalke) patient Mrs. Guerrero (Esther “Tita” Mercado) only speaks Spanish and might have lupus.

After making a diagnosis, each doctor tries to bond with their patient. When no one was watching, Mrs. Tanner left her room and went to the park with her family for a birthday party/picnic for her five-year-old granddaughter. After having some s’mores and cake, J.D. brought her back to the hospital. Turk and David take a moment and bond by watching a classic football game on television. Elliot has Carla (Judy Reyes) teach her some phrases in Spanish so she can communicate with Mrs. Guerrero.

Later, all of the patients develop life-ending complications. J.D., Turk, Elliot and Carla are in a state of shock since this is their first professional experience with death. But each of them learns that although death happens, life goes on.